Healthcare & Biotech ETFs

Which healthcare and biotech ETFs are the largest today? As of October 9, 2026, the five largest of the 39 healthcare and biotech ETFs ETF Copilot covers are XLV, VHT, IBB, XBI and IXJ, by assets. Expense ratios across the five run from 0.08% to 0.44% a year, and their ETF Copilot overall scores run from 4.0 to 5.4.

Updated October 9, 2026

What stands out across Healthcare & Biotech ETFs

Expense ratios across the 5 largest healthcare and biotech ETFs run from 0.08% to 0.44% a year, a median of 0.35%. XLV is the cheapest of the 5.

Across the 5 funds shown, ETF Copilot's overall scores run from 4.0 to 5.4 out of 10, with a median of 5.1.

Concentration varies widely among the 5 largest healthcare and biotech ETFs: the ten largest holdings account for 17% of assets in the least concentrated fund and 61% in the most, a median of 50% across the list.

2 of 5 are more concentrated than the typical fund in their own category, on ETF Copilot's concentration measure.

The typical fund among the 5 largest healthcare and biotech ETFs behaves like 30 equally weighted positions once holding weights are taken into account.

As of October 9, 2026, the largest Healthcare & Biotech ETFs fund by assets is State Street Health Care Select Sector SPDR ETF (XLV).

The 5 funds on this list

Healthcare & Biotech ETFs, listed largest first by assets. The 0–10 score is a separate composite measure, not the row order.
#	Fund	ETF Copilot score	Expense ratio	Assets	Top 10 weight	Largest exposures
1	State Street Health Care Select Sector SPDR ETF (XLV)	5.4/10	0.08%	$43.5B	61%	AI 0%
2	Vanguard Health Care ETF (VHT)	5.3/10	0.09%	$22.1B	52%	AI 0%, Tech 0%
3	iShares Biotechnology ETF (IBB)	4.0/10	0.44%	$10.4B	50%	AI 1%
4	State Street SPDR S&P Biotech ETF (XBI)	4.7/10	0.35%	$9.9B	17%
5	iShares Global Healthcare ETF (IXJ)	5.1/10	0.38%	$4.3B	48%	AI 0%

ETF Copilot's 0–10 score rates a fund on value, growth, quality and risk against every US equity ETF we track. How the scores are built →

Expense ratio, dividend yield and assets under management are reported by the fund and refreshed daily. Every other figure on this page is computed by ETF Copilot.

All 39 Healthcare & Biotech ETFs ETF Copilot covers

Which Healthcare & Biotech ETFs are compared head to head?

Every published head-to-head between two Healthcare & Biotech ETFs, the most searched first.

Where is money going in Health & Biotech?

In the week to October 9, 2026, Health & Biotech moved +1.2% and saw +$197M of net fund flow, which ETF Copilot reads as aligned — price and money moving the same way.

Health & Biotech — price move and net fund flow, as of October 9, 2026
Measure	Value
Price, 1 week	+1.2%
Net flow, 1 week	+$197M
Price, 1 month	+1.3%
Net flow, 1 month	+$1.3B

Net fund flow is money into or out of the ETFs in this category, computed by ETF Copilot from daily fund assets. All 33 sectors side by side →

Cite this

ETF Copilot, “Healthcare & Biotech ETFs — scores, concentration and exposure”, as of October 9, 2026.
https://etf-copilot.com/category/health-biotech

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