IBB vs XBI: holdings overlap, shared companies and scores
As of October 28, 2026, IBB and XBI overlap 43.5% by weight. iShares Biotechnology ETF (IBB): U.S. biotechnology stocks. State Street SPDR S&P Biotech ETF (XBI): U.S. biotech industry stocks.
Updated October 28, 2026
Where IBB trades against its own history
IBB trades at 28.9 times earnings, against its own median of 21.6, and is more expensive than 88% of its own last 7 years.
What moved IBB and XBI this week
IBB rose 2.3% in the week to October 28, 2026. The holdings that moved it most were Genmab A/S (+44.8%), Gilead Sciences (+3.7%) and Amgen (+3.1%); Moderna (−12.9%) pushed the other way.
XBI rose 3.1% in the week to October 28, 2026. The holdings that moved it most were Oruka Therapeutics (+20.1%), Twist Bioscience (+16.3%) and Grail (+19.1%); Moderna (−12.9%) pushed the other way.
What do IBB and XBI each hold?
What's inside IBB: AI 1%.
51% of IBB is its ten largest holdings.
18% of XBI is its ten largest holdings.
How much do IBB and XBI overlap? 43.5% by weight
As of October 28, 2026, IBB and XBI overlap 43.5% by weight.
76% of IBB is already inside XBI.
87% of XBI is already inside IBB.
IBB holds 240 companies and XBI holds 163; 122 are in both.
Computed by ETF Copilot from both funds' holdings rather than quoted from a data provider, and rebuilt nightly.
How does ETF Copilot score IBB and XBI? 4.3 and 4.9 out of 10
As of October 28, 2026, ETF Copilot scores IBB 4.3 out of 10 and XBI 4.9 out of 10.
They differ most on Risk: IBB 2.8 and XBI 1.2.
The five factor scores behind them are set out below, 0–10 and higher is better, ranked against every US equity ETF we track.
| Factor | IBB | XBI |
|---|---|---|
| Growth | 9.5 | 9.8 |
| Value | 0.2 | — |
| Risk | 2.8 | 1.2 |
| Quality | 0.9 | 0.3 |
| Return | 5.0 | 5.6 |
XBI is the cheaper of the two at 0.35% a year
As of October 28, 2026, IBB charges 0.44% a year, yields 0.14% and holds $11.0B in assets across 240 positions.
As of October 28, 2026, XBI charges 0.35% a year, yields 0.35% and holds $10.3B in assets across 163 positions.
| Measure | IBB | XBI |
|---|---|---|
| Expense ratio | 0.44% | 0.35% |
| Dividend yield | 0.14% | 0.35% |
| Assets under management | $11.0B | $10.3B |
| Holdings | 240 | 163 |
Expense ratio, dividend yield and assets under management are reported by the fund and refreshed daily. Every other figure on this page is computed by ETF Copilot.
Compare with similar funds
Cite this
ETF Copilot, “IBB vs XBI holdings overlap and scores”, as of October 28, 2026.
https://etf-copilot.com/compare/ibb-vs-xbi
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