SBIO vs VTWO: holdings overlap, shared companies and scores
As of October 9, 2026, SBIO and VTWO overlap 4.1% by weight. ALPS Medical Breakthroughs ETF (SBIO): Small- and mid-cap biotech firms. Vanguard Russell 2000 ETF (VTWO): U.S. small-cap stocks.
Updated October 9, 2026
Where VTWO trades against its own history
VTWO trades at 16.6 times earnings, against its own median of 16.9, and is cheaper than 57% of its own last 9 years.
What moved SBIO and VTWO this week
SBIO fell 2.0% in the week to October 9, 2026. The holdings that moved it most were Travere Therapeutics (−8.4%), Arrivent Biopharma (−40.8%) and Dianthus Therapeutics (−6.6%); Veradermics (+12.1%) pushed the other way.
VTWO fell 0.9% in the week to October 9, 2026. The holdings that moved it most were Twist Bioscience (−15.3%), Praxis Precision Medicines (−12.1%) and 10X Genomics (−13.7%); Vaxcyte (+26.4%) pushed the other way.
What do SBIO and VTWO each hold?
31% of SBIO is its ten largest holdings.
What's inside VTWO: Tech 14%, Semiconductors 2%.
3% of VTWO is its ten largest holdings.
How much do SBIO and VTWO overlap? 4.1% by weight
As of October 9, 2026, SBIO and VTWO overlap 4.1% by weight.
90% of SBIO is already inside VTWO.
4% of VTWO is already inside SBIO.
SBIO holds 104 companies and VTWO holds 1,988; 88 are in both.
Computed by ETF Copilot from both funds' holdings rather than quoted from a data provider, and rebuilt nightly.
How does ETF Copilot score SBIO and VTWO? 1.8 and 3.5 out of 10
As of October 9, 2026, ETF Copilot scores SBIO 1.8 out of 10 and VTWO 3.5 out of 10.
They differ most on Risk: SBIO 0.7 and VTWO 2.6.
The five factor scores behind them are set out below, 0–10 and higher is better, ranked against every US equity ETF we track.
| Factor | SBIO | VTWO |
|---|---|---|
| Risk | 0.7 | 2.6 |
| Quality | 0.3 | 0.6 |
| Return | 4.6 | 4.1 |
VTWO is the cheaper of the two at 0.06% a year
As of October 9, 2026, SBIO charges 0.50% a year and holds $187M in assets across 104 positions.
As of October 9, 2026, VTWO charges 0.06% a year, yields 1.20% and holds $18.4B in assets across 1988 positions.
| Measure | SBIO | VTWO |
|---|---|---|
| Expense ratio | 0.50% | 0.06% |
| Dividend yield | — | 1.20% |
| Assets under management | $187M | $18.4B |
| Holdings | 104 | 1988 |
Expense ratio, dividend yield and assets under management are reported by the fund and refreshed daily. Every other figure on this page is computed by ETF Copilot.
Compare with similar funds
Cite this
ETF Copilot, “SBIO vs VTWO holdings overlap and scores”, as of October 9, 2026.
https://etf-copilot.com/compare/sbio-vs-vtwo
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