PBE vs VTHR: holdings overlap, shared companies and scores
As of October 9, 2026, PBE and VTHR overlap 1.3% by weight. Invesco Biotechnology & Genome ETF (PBE): US biotech and genome stocks Vanguard Russell 3000 ETF (VTHR): U.S. total market stocks.
Updated October 9, 2026
Where PBE and VTHR trade against their own history
PBE trades at 25.3 times earnings, against its own median of 22.1, and is more expensive than 67% of its own last 9 years.
VTHR trades at 23.6 times earnings, against its own median of 22.2, and is more expensive than 62% of its own last 9 years.
What moved PBE and VTHR this week
PBE rose 1.9% in the week to October 9, 2026. The holdings that moved it most were Novavax (+21.9%), Moderna (+18.4%) and Gilead Sciences (+4.4%); Natera (−2.3%) pushed the other way.
VTHR rose 1.1% in the week to October 9, 2026. The holdings that moved it most were Microsoft (+3.4%), Amazon.com (+4.3%) and Alphabet (+2.4%); Nvidia (−2.0%) pushed the other way.
What do PBE and VTHR each hold?
48% of PBE is its ten largest holdings.
What's inside VTHR: Tech 40%, Magnificent 7 30%.
33% of VTHR is its ten largest holdings.
How much do PBE and VTHR overlap? 1.3% by weight
As of October 9, 2026, PBE and VTHR overlap 1.3% by weight.
98% of PBE is already inside VTHR.
1% of VTHR is already inside PBE.
PBE holds 30 companies and VTHR holds 2,972; 29 are in both.
Computed by ETF Copilot from both funds' holdings rather than quoted from a data provider, and rebuilt nightly.
How does ETF Copilot score PBE and VTHR? 4.8 and 6.6 out of 10
As of October 9, 2026, ETF Copilot scores PBE 4.8 out of 10 and VTHR 6.6 out of 10.
They differ most on Quality: PBE 1.8 and VTHR 7.6.
The five factor scores behind them are set out below, 0–10 and higher is better, ranked against every US equity ETF we track.
| Factor | PBE | VTHR |
|---|---|---|
| Growth | 9.7 | 6.7 |
| Value | 2.5 | 4.0 |
| Risk | 3.4 | 6.4 |
| Quality | 1.8 | 7.6 |
| Return | 4.3 | 7.6 |
VTHR is the cheaper of the two at 0.06% a year
As of October 9, 2026, PBE charges 0.59% a year, yields 1.36% and holds $410M in assets across 30 positions.
As of October 9, 2026, VTHR charges 0.06% a year, yields 1.01% and holds $6.4B in assets across 2972 positions.
| Measure | PBE | VTHR |
|---|---|---|
| Expense ratio | 0.59% | 0.06% |
| Dividend yield | 1.36% | 1.01% |
| Assets under management | $410M | $6.4B |
| Holdings | 30 | 2972 |
Expense ratio, dividend yield and assets under management are reported by the fund and refreshed daily. Every other figure on this page is computed by ETF Copilot.
Cite this
ETF Copilot, “PBE vs VTHR holdings overlap and scores”, as of October 9, 2026.
https://etf-copilot.com/compare/pbe-vs-vthr
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