SBIO vs VTHR: holdings overlap, shared companies and scores
As of October 9, 2026, SBIO and VTHR overlap 0.2% by weight. ALPS Medical Breakthroughs ETF (SBIO): Small- and mid-cap biotech firms. Vanguard Russell 3000 ETF (VTHR): U.S. total market stocks.
Updated October 9, 2026
Where VTHR trades against its own history
VTHR trades at 23.6 times earnings, against its own median of 22.2, and is more expensive than 62% of its own last 9 years.
What moved SBIO and VTHR this week
SBIO fell 2.0% in the week to October 9, 2026. The holdings that moved it most were Travere Therapeutics (−8.4%), Arrivent Biopharma (−40.8%) and Dianthus Therapeutics (−6.6%); Veradermics (+12.1%) pushed the other way.
VTHR rose 1.1% in the week to October 9, 2026. The holdings that moved it most were Microsoft (+3.4%), Amazon.com (+4.3%) and Alphabet (+2.4%); Nvidia (−2.0%) pushed the other way.
What do SBIO and VTHR each hold?
31% of SBIO is its ten largest holdings.
What's inside VTHR: Tech 40%, Magnificent 7 30%.
33% of VTHR is its ten largest holdings.
How much do SBIO and VTHR overlap? 0.2% by weight
As of October 9, 2026, SBIO and VTHR overlap 0.2% by weight.
90% of SBIO is already inside VTHR.
0% of VTHR is already inside SBIO.
SBIO holds 104 companies and VTHR holds 2,972; 88 are in both.
Computed by ETF Copilot from both funds' holdings rather than quoted from a data provider, and rebuilt nightly.
How does ETF Copilot score SBIO and VTHR? 1.8 and 6.6 out of 10
As of October 9, 2026, ETF Copilot scores SBIO 1.8 out of 10 and VTHR 6.6 out of 10.
They differ most on Quality: SBIO 0.3 and VTHR 7.6.
The five factor scores behind them are set out below, 0–10 and higher is better, ranked against every US equity ETF we track.
| Factor | SBIO | VTHR |
|---|---|---|
| Risk | 0.7 | 6.4 |
| Quality | 0.3 | 7.6 |
| Return | 4.6 | 7.6 |
VTHR is the cheaper of the two at 0.06% a year
As of October 9, 2026, SBIO charges 0.50% a year and holds $187M in assets across 104 positions.
As of October 9, 2026, VTHR charges 0.06% a year, yields 1.01% and holds $6.4B in assets across 2972 positions.
| Measure | SBIO | VTHR |
|---|---|---|
| Expense ratio | 0.50% | 0.06% |
| Dividend yield | — | 1.01% |
| Assets under management | $187M | $6.4B |
| Holdings | 104 | 2972 |
Expense ratio, dividend yield and assets under management are reported by the fund and refreshed daily. Every other figure on this page is computed by ETF Copilot.
Cite this
ETF Copilot, “SBIO vs VTHR holdings overlap and scores”, as of October 9, 2026.
https://etf-copilot.com/compare/sbio-vs-vthr
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